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MINI REVIEW

Effect of Acalabrutinib in Combination with Bendamustine plus Rituximab on Survival Endpoints in Older Patients with Mantle Cell Lymphoma: Insights from the ECHO Trial
December 09, 2024 CEST
Effect of Acalabrutinib in Combination with Bendamustine plus Rituximab on Survival Endpoints in Older Patients with Mantle Cell Lymphoma: Insights from the ECHO Trial
Adrian Schmidt

Promising findings from the ECHO trial suggest that integrating acalabrutinib with standard therapy could set a new standard for frontline treatment in older/unfit MCL patients.

Landmark PALOMA and MARIPOSA Studies Reveal the Impact of Amivantamab Alone and Combined with Lazertinib in Advanced NSCLC
June 28, 2024 CEST
Landmark PALOMA and MARIPOSA Studies Reveal the Impact of Amivantamab Alone and Combined with Lazertinib in Advanced NSCLC
Hiba MechahouguiLaure SmekensAlfredo Addeo

This mini-review summarizes the recent results of the phase II PALOMA study and the phase III MARIPOSA trial.

What is the Optimal Treatment Duration of Immunotherapy for NSCLC?
March 26, 2024 CEST
What is the Optimal Treatment Duration of Immunotherapy for NSCLC?
Sebastian KrausMathias Schmid

This article aims to explore the available data, as well as emerging approaches to biomarker analysis that may help to determine the optimal duration of IO treatment for NSCLC patients.

Endometrial Cancer: Updates in Molecular Characterization and Treatment Opportunities
March 26, 2024 CEST
Endometrial Cancer: Updates in Molecular Characterization and Treatment Opportunities
Matthew PowellMarcus Vetter

This review provides an overview of endometrial cancer epidemiology, its risk determinants, advancements in tumor molecular subtyping, and treatment recommendations from international guiding bodies.

March 26, 2024 CEST
Myelodysplastic Neoplasms: The Impact of Clonality on Inflammatory-Degenerative Diseases of the Elderly
Nicolas Bonadies

This paper highlights diagnostic challenges in the classification and risk stratification of patients with clonal hematopoiesis and myelodysplastic neoplasms, dysregulation of immune hemostasis and its impact on degenerative-inflammatory comorbidities.

December 21, 2023 CEST
Geriatric Assessment of Older Patients with Cancer: Recent Data and Updated Recommendations
Vérène DougoudMarcus Vetter

This paper focuses on recent data demonstrating the benefits of GA and GA-driven interventions on clinical outcomes of geriatric patients with cancer.

Current Challenges in Treating Unresectable Hepatocellular Carcinoma
December 09, 2023 CEST
Current Challenges in Treating Unresectable Hepatocellular Carcinoma
Jean-François Dufour

This article provides an overview of the complexities in the treatment of patients with HCC.

Advancing Ovarian Cancer Treatment: The Latest Insights on PARP Inhibitors from ASCO 2023
December 09, 2023 CEST
Advancing Ovarian Cancer Treatment: The Latest Insights on PARP Inhibitors from ASCO 2023
Yves van RoonMarcus Vetter

This review summarizes recent trials evaluating PARP inhibitors, as well as discusses remaining therapeutic challenges such as drug resistance and the quest for novel predictive biomarkers in ovarian cancer.

Swiss Amyloidosis Network (SAN): Objectives and Challenges
December 09, 2023 CEST
Swiss Amyloidosis Network (SAN): Objectives and Challenges
Rahel SchwotzerBernhard GerberAndreas FlammerAxel Rüfer

This article discusses the current diagnostic challenges and therapy options for systemic amyloidosis and summarizes the activities of the Swiss Amyloidosis Network (SAN).

PSMA-Directed Radioligand Therapy for Metastatic Prostate Cancer
December 09, 2023 CEST
PSMA-Directed Radioligand Therapy for Metastatic Prostate Cancer
Ellen Heitlinger

This mini-review discusses recent progress in radioligand therapy for metastatic prostate cancer.

December 01, 2023 CEST
Updates on Radiotherapy for Localized Prostate Cancer
Alexandros Papachristofilou

This article summarizes current challenges in prostate cancer management and recent updates in treatment strategies.

June 30, 2023 CEST
Surgical Therapy of Localized Prostate Cancer: Update on Treatment Approaches and Education Challenges
Svetozar Subotic

The article delves into the current controversies surrounding surgical approaches to prostatectomy and the challenges in educating urology residents.