|Absence of relevant cytopenia in the PB
||Relevant cytopenia in the PB for at least 4 months*
|No evidence of morphologic criteria for any hematologic neoplasm;
especially, no dysplasia or blast increase.
PNH, MGUS, and MBL excluded
|MDS-criteria not fulfilled: Dysplasia < 10%, no ring sideroblasts, no blast
increase, no MDS-defining cytogenetic alterations.
|Evidence of a somatic mutation that is associated with a hematologic neoplasm with a VAF of at least 2% (evidence of clonality)
|Annual risk of progression to hematologic neoplasm <0.5-1%
||Annual risk of progression to hematologic neoplasm >0.5-1%