Class	Gene	Proportion of total number of mutations (%)
Epigenetic Regulators	DNMT3A	58.1
	ASXL1	10.8
	TET2	9.5
	IDH2	0.3
RNA-splicing factors	SF3B1	4.0
	SRSF2	2.1
	U2AF1	0.3
Transcription factors	STAT3	0.3
Cell cycle regulators	TP53	1.2
	PPM1D	4.6
	ATM	0.3
Cell signaling molecules	JAK2	7.3
	CBL	0.9
	MYD88	0.3